[This paper is part of the Focused Collection on Instructional labs: Improving traditions and new directions.] Research on nontraditional laboratory (lab) activities in physics shows that students often expect to verify predetermined results, as takes place in traditional lab activities. This understanding of what is taking place, or epistemic framing, may impact students' behaviors in the lab, either productively or unproductively. In this paper, we present an analysis of student epistemic framing in a nontraditional lab with the aim of understanding how instructional context, specifically instructor behaviors, may shape student framing. We present video data from a lab section taught by an experienced teaching assistant (TA), with 19 students working in seven groups. We argue that student framing in this lab is evidenced by whether or not students articulate experimental predictions and by the extent to which they take up cognitive authority when constructing knowledge (epistemic agency). We show that the TA's attempts to shift student frames generally succeed with respect to experimental predictions but are less successful with respect to epistemic agency. In part, we suggest, the success of the TA's attempts reflects whether and how they are responsive to students' current framing. This work offers evidence that instructors can shift students' frames in nontraditional labs, while also illuminating the complexities of both student framing and the role of the instructor in shifting that framing in this context. © 2023 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.