We report on new instabilities of the quasistatic equilibrium of water drops pinned by a hydrophobic inclined substrate. The contact line of a statically pinned drop exhibits three transitions of partial depinning: depinning of the advancing and receding parts of the contact line and depinning of the entire contact line leading to the drop's translational motion. We find a region of parameters where the classical Macdougall-Ockrent-Frenkel approach fails to estimate the critical volume of the statically pinned inclined drop. © 2007 The American Physical Society.

When samples having volumes characteristic of protein crystals are plunge cooled in liquid nitrogen or propane, most cooling occurs in the cold gas layer above the liquid. By removing this cold gas layer, cooling rates for small samples and modest plunge velocities are increased to 1.5 × 104 K s-1, with increases of a factor of 100 over current best practice possible with 10 μm samples. Glycerol concentrations required to eliminate water crystallization in protein-free aqueous mixtures drop from ∼28% w/v to as low as 6% w/v.

The dependence of radiation damage to protein crystals at cryogenic temperatures upon the X-ray absorption cross-section of the crystal has been examined. Lysozyme crystals containing varying heavy-atom concentrations were irradiated and diffraction patterns were recorded as a function of the total number of incident photons. An experimental protocol and a coefficient of sensitivity to absorbed dose, proportional to the change in relative isotropic B factor, are defined that together yield a sensitive and robust measure of damage.

Vitrification of aqueous cryoprotectant mixtures is essential in cryopreservation of proteins and other biological samples. Systematic measurements of critical cryoprotective agent (CPA) concentrations required for vitrification during plunge-cooling from T = 295 K to T = 77 K in liquid nitrogen are reported.

We have fabricated longitudinal nanoconstrictions in the charge-density wave conductor (CDW) NbSe3 using a focused ion beam and using a mechanically controlled break-junction technique. Conductance peaks are observed below the TP1=145K and TP2=59K CDW transitions, which correspond closely with previous values of the full CDW gaps 2Δ1 and 2Δ2 obtained from photoemission. These results can be explained by assuming CDW-CDW tunneling in the presence of an energy gap corrugation 2 comparable to Δ2, which eliminates expected peaks at ±|Δ1+Δ2|.

We have probed the effects of transverse variations in pinning strength on charge-density-wave (CDW) structure in NbSe3 by x-ray micro-beam diffraction. In ribbonlike crystals having a large longitudinal step in thickness, the CDW first depins on the thick side of the step, causing rotations of the CDW wave vector. By measuring these rotations as a function of position and electric field, the corresponding shear strains are determined, allowing the CDW's shear modulus to be estimated.

The humble current-voltage (I-V) measurement has proven to be an extremely powerful probe of the physics of condensed matter systems from bulk semiconductors and superconductors to quantum dots and nanotubes. However, doing these deceptively simple measurements "right" so as to unambiguously extract particular bits of physics is hard. This is especially true of charge and spin density wave (CDW and SDW) conductors and related collective transport systems, in part because of the tremendous richness of their physics.

We have investigated the electrical transport properties of insulating and metallic constrictions of dimensions 10nm-10μm in the charge-density wave (CDW) conductor NbSe 3. The constrictions are made in a variety of ways: focused ion beam, reactive ion etching through a resist mask, and in a mechanically-controlled break junction configuration. We find that the behaviour of the junctions is independent of the fabrication method, and, depending on the size of the constriction, that the low-temperature behaviour of the constrictions is metallic or insulating.

The motion of protein drops on crystallization media during routine handling is a major factor affecting the reproducibility of crystallization conditions. Drop stability can be enhanced by chemical patterning to more effectively pin the drop's contact line. As an example, a hydrophilic area is patterned on an initially flat hydrophobic glass slide. The drop remains confined to the hydrophilic area and the maximum drop size that remains stable when the slide is rotated to the vertical position increases.

In whisker-like samples of the quasi-1D conductor NbSe3, the presence of longitudinal steps causes shearing of the CDW, and leads to a loss of transverse correlations. We use a microdiffraction setup with a spatial resolution of 300 nm and an angular sensitivity of 5 indeg to image the resulting CDW contrast between thick and thin portions of the sample.