$\mathrm{krbEGF}\mathrm{EGF}\mathrm{freeEGFReceptor}$ $\mathrm{kruEGF}\mathrm{boundEGFReceptor}$ $\mathrm{krbNGF}\mathrm{NGF}\mathrm{freeNGFReceptor}$ $\mathrm{kruNGF}\mathrm{boundNGFReceptor}$ $\frac{\mathrm{kEGF}\mathrm{boundEGFReceptor}\mathrm{SosInactive}}{\mathrm{SosInactive}+\mathrm{KmEGF}}$ $\frac{\mathrm{kNGF}\mathrm{boundNGFReceptor}\mathrm{SosInactive}}{\mathrm{SosInactive}+\mathrm{KmNGF}}$ $\frac{\mathrm{kdSos}\mathrm{P90RskActive}\mathrm{SosActive}}{\mathrm{SosActive}+\mathrm{KmdSos}}$ $\frac{\mathrm{kSos}\mathrm{SosActive}\mathrm{RasInactive}}{\mathrm{RasInactive}+\mathrm{KmSos}}$ $\frac{\mathrm{kRasGap}\mathrm{RasGapActive}\mathrm{RasActive}}{\mathrm{RasActive}+\mathrm{KmRasGap}}$ $\frac{\mathrm{kRasToRaf1}\mathrm{RasActive}\mathrm{Raf1Inactive}}{\mathrm{Raf1Inactive}+\mathrm{KmRasToRaf1}}$ $\frac{\mathrm{kpRaf1}\mathrm{Raf1Active}\mathrm{MekInactive}}{\mathrm{MekInactive}+\mathrm{KmpRaf1}}$ $\frac{\mathrm{kpBRaf}\mathrm{BRafActive}\mathrm{MekInactive}}{\mathrm{MekInactive}+\mathrm{KmpBRaf}}$ $\frac{\mathrm{kpMekCytoplasmic}\mathrm{MekActive}\mathrm{ErkInactive}}{\mathrm{ErkInactive}+\mathrm{KmpMekCytoplasmic}}$ $\frac{\mathrm{kdMek}\mathrm{PP2AActive}\mathrm{MekActive}}{\mathrm{MekActive}+\mathrm{KmdMek}}$ $\frac{\mathrm{kdErk}\mathrm{PP2AActive}\mathrm{ErkActive}}{\mathrm{ErkActive}+\mathrm{KmdErk}}$ $\frac{\mathrm{kdRaf1}\mathrm{Raf1PPtase}\mathrm{Raf1Active}}{\mathrm{Raf1Active}+\mathrm{KmdRaf1}}$ $\frac{\mathrm{kpP90Rsk}\mathrm{ErkActive}\mathrm{P90RskInactive}}{\mathrm{P90RskInactive}+\mathrm{KmpP90Rsk}}$ $\frac{\mathrm{kPI3K}\mathrm{boundEGFReceptor}\mathrm{PI3KInactive}}{\mathrm{PI3KInactive}+\mathrm{KmPI3K}}$ $\frac{\mathrm{kPI3KRas}\mathrm{RasActive}\mathrm{PI3KInactive}}{\mathrm{PI3KInactive}+\mathrm{KmPI3KRas}}$ $\frac{\mathrm{kAkt}\mathrm{PI3KActive}\mathrm{AktInactive}}{\mathrm{AktInactive}+\mathrm{KmAkt}}$ $\frac{\mathrm{kdRaf1ByAkt}\mathrm{AktActive}\mathrm{Raf1Active}}{\mathrm{Raf1Active}+\mathrm{KmRaf1ByAkt}}$ $\frac{\mathrm{kC3GNGF}\mathrm{boundNGFReceptor}\mathrm{C3GInactive}}{\mathrm{C3GInactive}+\mathrm{KmC3GNGF}}$ $\frac{\mathrm{kC3G}\mathrm{C3GActive}\mathrm{Rap1Inactive}}{\mathrm{Rap1Inactive}+\mathrm{KmC3G}}$ $\frac{\mathrm{kRapGap}\mathrm{RapGapActive}\mathrm{Rap1Active}}{\mathrm{Rap1Active}+\mathrm{KmRapGap}}$ $\frac{\mathrm{kRap1ToBRaf}\mathrm{Rap1Active}\mathrm{BRafInactive}}{\mathrm{BRafInactive}+\mathrm{KmRap1ToBRaf}}$ $\frac{\mathrm{kdBRaf}\mathrm{Raf1PPtase}\mathrm{BRafActive}}{\mathrm{BRafActive}+\mathrm{KmdBRaf}}$